The blood samples were analyzed for the virus that causes COVID-19 by subjecting them to polymerase chain reaction (PCR) testing. Epub 2021 Nov 10. -, Walsh E.E., Frenck R.W., Jr., Falsey A.R., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Mulligan M.J., Bailey R., et al. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more The study has received a lot of media attention, what are your thoughts on that? A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. This has been the question our study aims to answer. This site needs JavaScript to work properly. Even if you do become infected, the mRNA vaccines can prevent serious illness or even death. The researchers write that the findings warrant a further Pfizer Vaccine Becomes DNA in Liver Cells. J. Med. It was assumed that the vaccines spike protein would remain mostly at the injection site and last up to several weeks like other proteins produced in the body. Genomics, diabetes and endocrinologyyang [dot] de_marinis [at] med [dot] lu [dot] se, Box 117, 221 00 Lund, Sweden Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines. Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination by ChAdOx1nCov-19. Current Issues in Molecular Biology. You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. Finally, as the authors pointed out, expression of LINE-1 has been shown to increase during viral infections, including with SARS-CoV-2 virus. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. 5. Some viruses, like HIV, are known to be able to convert RNA to DNA and then incorporate that DNA into host cells genome, which is one thing that makes the illness difficult to treat. Table S1 summaries the vaccines Lund University Suggested accounts. The Japanese regulatory agencys biodistribution study (pdf) of the Pfizer vaccine showed that some of the mRNAs moved from the injection site and through the bloodstream, and were found in various organs such as the liver, spleen, adrenal glands, and ovaries of rats 48 hours following injection. Pfizers COVID trials6 enrolled 46,331 participants in a Phase 3 clinical trial while Recombivax HB tested just 147 infants and children. Accessibility statement. We show that the vaccine enters liver cells as Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Cureus. 2022 Nov;28(11):2273-2287. doi: 10.1038/s41591-022-02061-1. eCollection 2022 Dec. Mavridis C, Aidonidis G, Evangelou M, Kalogeridis A. Hist Philos Life Sci. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. (In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 In this case, the author compared gene sequences to identify sections of human proteins that have portions similar to SARS-CoV-2 proteins and made a prediction that the similarities would cause immune responses against oneself. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. The results have in many cases been misinterpreted, the Q&A also stated. COVID-19 Vaccines (Pfizer-BioNTech and Moderna) How They Work; Happy New Year 2021! 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. Because the study design does not necessarily reflect what happens in most human bodies, he said the findings cannot be extrapolated to make inferences about what would happen in human subjects. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. -. The text in one post reads: BOMBSHELL: Biological Study PROVES Pfizer mRNA Vaccine Permanently Alters Human DNA. (In-vitro Swedish Study)\r\rAn accepted and published Swedish study demonstrates for the first time the presence of Pfizer-BionTech vaccine DNA in the cell. In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. In order to create these cell lines, the genetic make-up of the cells has to be fiddled with to make them immortal and keep them alive in the petri dish, Dr. David Strain, a senior clinical lecturer at Englands University of Exeter Medical School, wrote in an email to the AP. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. This has been the question our study aims to answer. eCollection 2022. in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumour. WebSkip to topic navigation. Let's review.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. Additionally, the mRNA vaccine does in fact travel to the liver and other locations such as ovaries. N. Engl. https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support). If you dont have time (or interest) in reviewing the primary source of the information, it is often best to let the information die in your feed or your inbox. Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. These cells have had the normal protections of the immune system removed.. The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. It is important to bear in mind that the liver cells in this study are more genetically unstable than our own liver cells. This article was produced by the Reuters Fact Check team. The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). Alden M, Falla FO, Yang D, et al. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. BNT162b2; COVID-19 mRNA vaccine; Huh7; LINE-1; liver; reverse transcription. PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. The pharmaceutical industry is dangerous to health. yourNEWS is a hyper-local social news and advertising platform. doi: 10.1056/NEJMc2107717. WebPfizer Vaccine Becomes DNA in Liver Cells. 2022 Apr;28(4):612.e1-612.e7. , ! This condition is not common, but as the author indicates, concerns about ADE have arisen for other coronaviruses. First, cancerous cell lines replicate, whereas our liver cells typically are not replicating. The mRNA in the COVID-19 vaccines helps train the body to recognize a protein from the coronavirus to trigger an immune response. Associate Professor Invasion of Ukraine: Russia and Ukraine ready for second round of talks tonight. Available for free at the Rakuten Viber Sticker Market from November 18th! Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. The authors of thefirst reported caseof a healthy 35-year-old female who developed autoimmune hepatitis a week after her first dose of the Pfizer COVID-19 vaccine said that there is a possibility that spike-directed antibodies induced by vaccination may also trigger autoimmune conditions in predisposed individuals as it has been shown that severe cases of SARS-CoV-2 infection are characterized by an autoinflammatory dysregulation that contributes to tissue damage, which the viruss spike protein appears to be responsible for. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. We show that the vaccine enters liver cells as early as 6 hours after the vaccine has been administered. (In-vitro Swedish Study) An accepted and published Swedish study demonstrates for the Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. Webpfizer vaccine becomes dna in liver cells. These vaccines deliver genetic material that instructs cells to begin making spike proteins found on the surface of SARS-CoV-2 that causes COVID-19 to produce an immune response. One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies, de Marinis said. The mRNA is converted to DNA as early as six hours after exposure to the vaccine. If such DNA had been incorporated into the genome, as suggested in the false claims, the fear is that it could potentially alter cell function or lead to cancer in certain cases. Our COVID-19 vaccine does not alter the DNA sequence of a human cell, a Pfizer spokesperson told The Epoch Times in an email. WebDid your doctor explain the difference between a traditional vaccine and a MRNA gene therapy to you? MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. This means that what is seen in these cells may not be representative of what would happen in non-cancerous liver cells (or even a different line of cancerous liver cells). Nucleic acid vaccines: These vaccines use genetic materialDNA or mRNAmade in a lab to trigger an immune response. However, this is not an appropriate conclusion from this paper for several reasons: Logical fallacy called hasty generalization (It is important to note in this case, that the misconception was not because of the quality of the science or the messaging of the authors, but rather because others took the findings out of context.). MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. Currently the Pfizer-Biontech (mRNA), Sinovac (inactivated virus) and Astrazeneca-Oxford (adenovirus-vector) COVID-19 vaccines are available for vaccination in HK. You should not use it to replace any relationship with a physician or other qualified healthcare professional. DNA, which makes up our genetic code, is larger, double stranded and very long. Antibody levels were also measured in separate tests. Its the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, the Epoch Times reported. As such, finding similar stretches of genes is not novel, unlikely, or particularly surprising. Further, the newest vaccines are personalized, meaning they can target a patients The authors also made this point by stating, The exact regulation of LINE-1 activity in response to BNT162b2 merits further study. (p. 1123). Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. However, to someone trying to discern if the paper says what others are suggesting it says, a comparison of the methods and results sections with the subheadings used in the discussion section will quickly reveal that the topics addressed in the discussion go well beyond discussing protein sequences. AP'S ASSESSMENT: False. 2023 Jan 19. Published on Microbiol Spectr. Each dot on the table represents a study subject. An official website of the United States government. "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. A gene that the researchers studied produces the protein LINE-1. 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